Rasagiline is neuroprotective in an experimental
model of brain ischemia in the rat
by
Speiser Z, Mayk A, Litinetsky L, Fine T, Nyska A, Blaugrund E, Cohen S.
Department of Physiology and Pharmacology,
Sackler School of Medicine,
Tel Aviv University,
Ramat Aviv, Israel
J Neural Transm. 2006 Dec 21;
ABSTRACTThe neuroprotective effects of intravenous rasagiline were investigated in a rat model of stroke. Middle cerebral artery (MCA) occlusion was performed in male rats and the short- (neurological severity score [NSS], infarct size), intermediate- (cognition) and long-term (necrotic area) effects were assessed. A bolus (3 mg/kg) of rasagiline followed by a 3-h infusion (3 mg/kg/h), initiated immediately after MCA occlusion, reduced infarct size by 48.6% and NSS by 32.7% relative to saline treatment. Cognitive function, tested in a water maze 2-3 weeks after occlusion, also significantly improved compared with saline-treated controls. Necrotic brain area was 35-50% smaller with rasagiline than with saline following a single bolus dose. The single bolus rasagiline dose was as effective as a rasagiline bolus followed by rasagiline infusion in short-term outcomes. The neuroprotective effect of rasagiline was fully reproducible when administered at 2 h following occlusion but not after 4 h.and further reading
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